Bmi‐1‐RING1B prevents GATA4‐dependent senescence‐associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4

Abstract Aims Senescence‐associated pathological cardiac hypertrophy (SA‐PCH) is associated with upregulation of foetal genes, fibrosis, senescence‐associated secretory phenotype (SASP), cardiac dysfunction and increased morbidity and mortality. Therefore, we conducted experiments to investigate whe...

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Detalhes bibliográficos

Principais autores:	Haiyun Chen, Jiawen Zhou, Hongjie Chen, Jialong Liang, Chunfeng Xie, Xin Gu, Rong Wang, Zhiyuan Mao, Yongjie Zhang, Qing Li, Guoping Zuo, Dengshun Miao, Jianliang Jin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2022-04-01
coleção:	Clinical and Translational Medicine
Assuntos:	Bmi‐1 GATA4 RING1B selective autophagy ubiquitination
Acesso em linha:	https://doi.org/10.1002/ctm2.574
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