Bmi‐1‐RING1B prevents GATA4‐dependent senescence‐associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4

Abstract Aims Senescence‐associated pathological cardiac hypertrophy (SA‐PCH) is associated with upregulation of foetal genes, fibrosis, senescence‐associated secretory phenotype (SASP), cardiac dysfunction and increased morbidity and mortality. Therefore, we conducted experiments to investigate whe...

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Dettagli Bibliografici

Autori principali:	Haiyun Chen, Jiawen Zhou, Hongjie Chen, Jialong Liang, Chunfeng Xie, Xin Gu, Rong Wang, Zhiyuan Mao, Yongjie Zhang, Qing Li, Guoping Zuo, Dengshun Miao, Jianliang Jin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2022-04-01
Serie:	Clinical and Translational Medicine
Soggetti:	Bmi‐1 GATA4 RING1B selective autophagy ubiquitination
Accesso online:	https://doi.org/10.1002/ctm2.574
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