Sustainable Protocol for the Synthesis of 2′,3′-Dideoxynucleoside and 2′,3′-Didehydro-2′,3′-dideoxynucleoside Derivatives

An improved protocol for the transformation of ribonucleosides into 2′,3′-dideoxynucleoside and 2′,3′-didehydro-2′,3′-dideoxynucleoside derivatives, including the anti-HIV drugs stavudine (d4T), zalcitabine (ddC) and didanosine (ddI), was established. The process involves radical deoxygenation of xa...

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Autori principali:	Virginia Martín-Nieves, Yogesh S. Sanghvi, Susana Fernández, Miguel Ferrero
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2022-06-01
Serie:	Molecules
Soggetti:	2′,3′-dideoxynucleosides 2′,3′-didehydro-2′,3′-dideoxynucleosides synthesis zalcitabine (ddC) didanosine (ddI) stavudine (d4T)
Accesso online:	https://www.mdpi.com/1420-3049/27/13/3993
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