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APP Causes Hyperexcitability in Fragile X Mice

Amyloid-beta protein precursor (APP) and metabolite levels are altered in fragile X syndrome (FXS) patients and in the mouse model of the disorder, Fmr1KO mice. Normalization of APP levels in Fmr1KO mice (Fmr1KO/APPHET mice) rescues many disease phenotypes. Thus, APP is a potential biomarker as well...

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Principais autores: Cara Jean Westmark, Shih-Chieh Chuang, Seth A Hays, Mikolaj J Filon, Brian C Ray, Pamela R Westmark, Jay R Gibson, Kimberly M Huber, Robert KS Wong
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016-12-01
Serier:Frontiers in Molecular Neuroscience
Fag:
Fragile X Mental Retardation Protein
Fragile X Syndrome
hyperexcitability
amyloid-beta
Amyloid-beta precursor protein
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00147/full
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