APP Causes Hyperexcitability in Fragile X Mice
Amyloid-beta protein precursor (APP) and metabolite levels are altered in fragile X syndrome (FXS) patients and in the mouse model of the disorder, Fmr1KO mice. Normalization of APP levels in Fmr1KO mice (Fmr1KO/APPHET mice) rescues many disease phenotypes. Thus, APP is a potential biomarker as well...
Guardat en:
| Autors principals: | , , , , , , , , |
|---|---|
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Frontiers Media S.A.
2016-12-01
|
| Col·lecció: | Frontiers in Molecular Neuroscience |
| Matèries: | |
| Accés en línia: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00147/full |
| Etiquetes: |
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|