A_2A Adenosine Receptor Antagonists and Their Efficacy in Rat Models of Parkinson’s Disease

Parkinson’s disease (PD) represents a growing challenge to global health, as it involves millions of people. The high grade of disability is due to the loss of dopaminergic neuron activity, and levodopa is the gold-standard therapy used to restore dopamine in the dopamine-denervated regions. Another...

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Główni autorzy:	Andrea Spinaci, Michela Buccioni, Diego Dal Ben, Beatrice Francucci, Karl-Norbert Klotz, Gabriella Marucci, Nicola Simola, Micaela Morelli, Annalisa Pinna, Rosaria Volpini, Catia Lambertucci
Format:	Artigo
Język:	Inglês
Wydane:	MDPI AG 2025-02-01
Seria:	Cells
Hasła przedmiotowe:	adenosine receptor ligands adenosine receptor antagonists synthesis of purine derivatives binding and functional assays <i>in vivo</i> models of Parkinson’s disease medicinal chemistry
Dostęp online:	https://www.mdpi.com/2073-4409/14/5/338
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