The AMPK-like protein kinases Sik2 and Sik3 interact with Hipk and induce synergistic tumorigenesis in a Drosophila cancer model

Homeodomain-interacting protein kinases (Hipks) regulate cell proliferation, apoptosis, and tissue development. Overexpression of Hipk in Drosophila causes tumorigenic phenotypes in larval imaginal discs. We find that depletion of Salt-inducible kinases Sik2 or Sik3 can suppress Hipk-induced overgro...

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Principais autores:	Kewei Yu, Niveditha Ramkumar, Kenneth Kin Lam Wong, Gritta Tettweiler, Esther M. Verheyen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-10-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	Drosophila models of cancer HIPK Sik cancer synergy imaginal discs signal transduction
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2023.1214539/full
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