Stepwise activation of the ATR signaling pathway upon increasing replication stress impacts fragile site integrity.

Breaks at common fragile sites (CFS) are a recognized source of genome instability in pre-neoplastic lesions, but how such checkpoint-proficient cells escape surveillance and continue cycling is unknown. Here we show, in lymphocytes and fibroblasts, that moderate replication stresses like those indu...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Stéphane Koundrioukoff, Sandra Carignon, Hervé Técher, Anne Letessier, Olivier Brison, Michelle Debatisse
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Public Library of Science (PLoS) 2013-01-01
Цуврал:	PLoS Genetics
Онлайн хандалт:	http://europepmc.org/articles/PMC3715430?pdf=render
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!