Stepwise activation of the ATR signaling pathway upon increasing replication stress impacts fragile site integrity.
Breaks at common fragile sites (CFS) are a recognized source of genome instability in pre-neoplastic lesions, but how such checkpoint-proficient cells escape surveillance and continue cycling is unknown. Here we show, in lymphocytes and fibroblasts, that moderate replication stresses like those indu...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2013-01-01
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| Colecção: | PLoS Genetics |
| Acesso em linha: | http://europepmc.org/articles/PMC3715430?pdf=render |
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