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Sonic hedgehog is basolaterally sorted from the TGN and transcytosed to the apical domain involving Dispatched-1 at Rab11-ARE

Hedgehog proteins (Hhs) secretion from apical and/or basolateral domains occurs in different epithelial cells impacting development and tissue homeostasis. Palmitoylation and cholesteroylation attach Hhs to membranes, and Dispatched-1 (Disp-1) promotes their release. How these lipidated proteins are...

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Principais autores: Lisette Sandoval, Mariana Labarca, Claudio Retamal, Paula Sánchez, Juan Larraín, Alfonso González
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-12-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
hedgehog
polarity
trafficking
Dispatched
Rab11-ARE
transcytosis
Online adgang:https://www.frontiersin.org/articles/10.3389/fcell.2022.833175/full
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