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Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Abstract Cisplatin (CDDP) is a highly effective chemotherapy drug with broad clinical utility. Yet its therapeutic application is significantly constrained by off‐target toxicities, especially nephrotoxicity. However, the molecular mechanisms underlying CDDP‐induced kidney injury remain incompletely...

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Principais autores: Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-02-01
Serier:Advanced Science
Fag:
cisplatin
icaritin
mitochondrial dysfunction
multi‐omics
nephrotoxicity
Online adgang:https://doi.org/10.1002/advs.202506712
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