Diacylglycerol kinase ζ limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes

Background The inhibitory functions triggered by the programmed cell death-1 (PD-1) receptor following binding to its ligand (PD-L1) protect healthy organs from cytotoxic T cells, and neutralize antitumor T cell attack. Antibody-based therapies to block PD-1/PD-L1 interaction have yielded notable re...

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主要な著者:	Judith Leitner, Peter Steinberger, Javier Arranz-Nicolas, Cristina Rodríguez-Rodríguez, Rosa Liébana, Antonia Ávila-Flores, Isabel Mérida, Miguel Martin-Salgado, Maria C Moreno-Ortiz
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMJ Publishing Group 2020-10-01
シリーズ:	Journal for ImmunoTherapy of Cancer
オンライン･アクセス:	https://jitc.bmj.com/content/8/2/e001521.full
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