Fenofibrate mitigates the dysfunction of high glucose-driven human retinal microvascular endothelial cells by suppressing NLRP3 inflammasome

AIM: To determine the therapeutic benefits of fenofibrate (Feno) on the dysfunction of high glucose (HG)-induced human retinal microvascular endothelial cells (HRMECs) and to elucidate the underlying molecular mechanism. METHODS: HRMEC dysfunction model was established by 48h glucose (30 mmol/L) tre...

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Principais autores:	Yi Shi, Hao-Min Chen, Ai-Hua Liu, Xiao-Rong Li
Formato:	Artigo
Idioma:	Inglês
Publicado:	Press of International Journal of Ophthalmology (IJO PRESS) 2025-05-01
Series:	International Journal of Ophthalmology
Assuntos:	fenofibrate human retinal microvascular endothelial cells high glucose nod-like receptor thermal protein domain associated protein 3 inflammasomes oxidative stress
Acceso en liña:	http://ies.ijo.cn/en_publish/2025/5/20250504.pdf
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