Fenofibrate mitigates the dysfunction of high glucose-driven human retinal microvascular endothelial cells by suppressing NLRP3 inflammasome

AIM: To determine the therapeutic benefits of fenofibrate (Feno) on the dysfunction of high glucose (HG)-induced human retinal microvascular endothelial cells (HRMECs) and to elucidate the underlying molecular mechanism. METHODS: HRMEC dysfunction model was established by 48h glucose (30 mmol/L) tre...

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Hlavní autoři:	Yi Shi, Hao-Min Chen, Ai-Hua Liu, Xiao-Rong Li
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Press of International Journal of Ophthalmology (IJO PRESS) 2025-05-01
Edice:	International Journal of Ophthalmology
Témata:	fenofibrate human retinal microvascular endothelial cells high glucose nod-like receptor thermal protein domain associated protein 3 inflammasomes oxidative stress
On-line přístup:	http://ies.ijo.cn/en_publish/2025/5/20250504.pdf
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