Pharmacokinetic and Pharmacodynamic Characterisation of an Anti-Mouse TNF Receptor 1 Domain Antibody Formatted for In Vivo Half-Life Extension.

Tumour Necrosis Factor-α (TNF-α) inhibition has been transformational in the treatment of patients with inflammatory disease, e.g. rheumatoid arthritis. Intriguingly, TNF-α signals through two receptors, TNFR1 and TNFR2, which have been associated with detrimental inflammatory and beneficial immune-...

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Hlavní autoři:	Laura J Goodall, Milan Ovecka, Daniel Rycroft, Sarah L Friel, Andrew Sanderson, Prafull Mistry, Marie L Davies, A Allart Stoop
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2015-01-01
Edice:	PLoS ONE
On-line přístup:	http://europepmc.org/articles/PMC4564187?pdf=render
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