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Liver-targeting of interferon-alpha with tissue-specific domain antibodies.

Interferon alpha (IFNα) is used for the treatment of hepatitis C infection and whilst efficacious it is associated with multiple adverse events including reduced leukocyte, erythrocyte, and platelet counts, fatigue, and depression. These events are most likely caused by systemic exposure to interfer...

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Autori principali: Edward Coulstock, Jane Sosabowski, Milan Ovečka, Rob Prince, Laura Goodall, Clare Mudd, Armin Sepp, Marie Davies, Julie Foster, Jerome Burnet, Gráinne Dunlevy, Adam Walker
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2013-01-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC3581439?pdf=render
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