The AKAP12-PKA axis regulates lipid homeostasis during alcohol-associated liver disease
Abstract Disrupted lipogenic signaling and steatosis are key features of alcohol-associated liver disease (ALD). A-kinase anchoring protein 12 (AKAP12) is a scaffolding partner of the cAMP-dependent protein kinase, PKA that controls its spatiotemporal localization. Activation of PKA by cAMP inhibits...
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| Principais autores: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2025-04-01
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| Serier: | Signal Transduction and Targeted Therapy |
| Online adgang: | https://doi.org/10.1038/s41392-025-02202-1 |
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