The AKAP12-PKA axis regulates lipid homeostasis during alcohol-associated liver disease

Abstract Disrupted lipogenic signaling and steatosis are key features of alcohol-associated liver disease (ALD). A-kinase anchoring protein 12 (AKAP12) is a scaffolding partner of the cAMP-dependent protein kinase, PKA that controls its spatiotemporal localization. Activation of PKA by cAMP inhibits...

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Autors principals:	Chandana Thimme Gowda, Mallikarjuna Siraganahalli Eshwaraiah, Jiaohong Wang, Youngyi Lim, Maria Lauda Tomasi, Nirmala Mavila, Komal Ramani
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2025-04-01
Col·lecció:	Signal Transduction and Targeted Therapy
Accés en línia:	https://doi.org/10.1038/s41392-025-02202-1
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