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Activation of the Protein Kinase R?Like Endoplasmic Reticulum Kinase (PERK) Pathway of the Unfolded Protein Response after Experimental Traumatic Brain Injury and Treatment with a PERK Inhibitor

Neurodegeneration after traumatic brain injury (TBI) is increasingly recognized as a key factor contributing to poor chronic outcomes. Activation (i.e., phosphorylation) of the protein kinase R-like endoplasmic reticulum kinase (PERK) pathway has been implicated in neurodegenerative conditions with...

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Автори: Rhys D. Brady, Stefanie Bird, Mujun Sun, Glenn R. Yamakawa, Brendan P. Major, Richelle Mychasiuk, Terence J. O'Brien, Stuart J. McDonald, Sandy R. Shultz
Формат: Artigo
Мова:Inglês
Опубліковано: SAGE Publishing 2021-07-01
Серія:Neurotrauma Reports
Предмети:
eukaryotic translation initiation factor ?
fluid percussion injury
GSK2606414
misfolded proteins
neurodegeneration
protein kinase RNA-like ER kinase
Онлайн доступ:https://www.liebertpub.com/doi/full/10.1089/NEUR.2021.0001
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