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The multifaceted role of PUMA in cell death pathways: its therapeutic potential across cancer types

Abstract Cell death is a fundamental process essential to all living organisms, with apoptosis serving as one of the most crucial pathways across various stages of life. Dysregulation of apoptosis is closely associated with numerous diseases, particularly cancer. PUMA (p53 upregulated modulator of a...

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Glavni autori: Sharad Shriram Tat, Kartik Mandal, Tanisha Sharma, Nikhil Baban Ghate, Ganesh Kumar Barik, Rajesh N. Gachhe, Manas Kumar Santra
Format: Artigo
Jezik:Inglês
Izdano: BMC 2025-11-01
Serija:Cell Communication and Signaling
Teme:
PUMA
Apoptosis
Drug resistance
Autophagy
Necroptosis
Ferroptosis
Online pristup:https://doi.org/10.1186/s12964-025-02112-3
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