NK cell-mediated tumor cell killing by bispecific innate cell engagers induces ADCC-mediated activation of primary human dendritic cells

Bispecific antibodies are used for the treatment of hematological malignancies as well as solid tumors. One of their main effector mechanisms is the recruitment of effector cells such as CD8+ T cells and CD16A+ NK cells to tumor cells. Bispecific innate cell engagers (ICE®) harnessing CD16A+ NK cell...

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Bibliografische Detailangaben

Hauptverfasser:	Lukas Heger, Tomasz Kaszubowski, Lukas Amon, Christian H. K. Lehmann, Susanne Wingert, José Medina-Echeverz, Joachim Koch, Holger Hackstein, Ariawan Purbojo, Arndt Hartmann, Christoph Alexiou, Robert Cesnjevar, Jens Pahl, Diana Dudziak
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2026-12-01
Schriftenreihe:	OncoImmunology
Schlagworte:	Bispecific antibodies AFM24 NK cell CD16A EGFR dendritic cells
Online-Zugang:	https://www.tandfonline.com/doi/10.1080/2162402X.2026.2613561
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