NK cell-mediated tumor cell killing by bispecific innate cell engagers induces ADCC-mediated activation of primary human dendritic cells

Bispecific antibodies are used for the treatment of hematological malignancies as well as solid tumors. One of their main effector mechanisms is the recruitment of effector cells such as CD8+ T cells and CD16A+ NK cells to tumor cells. Bispecific innate cell engagers (ICE®) harnessing CD16A+ NK cell...

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主要な著者:	Lukas Heger, Tomasz Kaszubowski, Lukas Amon, Christian H. K. Lehmann, Susanne Wingert, José Medina-Echeverz, Joachim Koch, Holger Hackstein, Ariawan Purbojo, Arndt Hartmann, Christoph Alexiou, Robert Cesnjevar, Jens Pahl, Diana Dudziak
フォーマット:	Artigo
言語:	Inglês
出版事項:	Taylor & Francis Group 2026-12-01
シリーズ:	OncoImmunology
主題:	Bispecific antibodies AFM24 NK cell CD16A EGFR dendritic cells
オンライン･アクセス:	https://www.tandfonline.com/doi/10.1080/2162402X.2026.2613561
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