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Development of mAb-based polyglutamine-dependent and polyglutamine length-independent huntingtin quantification assays with cross-site validation.

Huntington's disease (HD) is caused by an expansion of the CAG trinucleotide repeat domain in the huntingtin gene that results in expression of a mutant huntingtin protein (mHTT) containing an expanded polyglutamine tract in the amino terminus. A number of therapeutic approaches that aim to reduce m...

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Principais autores: David F Fischer, Sipke Dijkstra, Kimberly Lo, Johnny Suijker, Ana C P Correia, Patricia Naud, Martin Poirier, Michela A Tessari, Ivette Boogaard, Geraldine Flynn, Mijke Visser, Marieke B A C Lamers, George McAllister, Ignacio Munoz-Sanjuan, Douglas Macdonald
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2022-01-01
Serier:PLoS ONE
Online adgang:https://doi.org/10.1371/journal.pone.0266812
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