A cautionary perspective regarding the isolation and serial propagation of SARS-CoV-2 in Vero cells

Abstract An array of SARS-CoV-2 virus variants have been isolated, propagated and used in in vitro assays, in vivo animal studies and human clinical trials. Observations of working stocks of SARS-CoV-2 suggest that sequential propagation in Vero cells leads to critical changes in the region of the f...

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Principais autores:	Simon G. P. Funnell, Babak Afrough, John James Baczenas, Neil Berry, Kevin R. Bewley, Rebecca Bradford, Clint Florence, Yann Le Duff, Mark Lewis, Ryan V. Moriarty, Shelby L. O. Connor, Karen L. Osman, Steven Pullan, Sujatha Rashid, Kevin S. Richards, Kimberly J. Stemple, Ivana Knezevic
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2021-06-01
Series:	npj Vaccines
Acceso en liña:	https://doi.org/10.1038/s41541-021-00346-z
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