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GPX4 alleviates airway inflammation by suppressing 5-LO expression and regulating ferroptosis

Abstract Ferroptosis has been increasingly implicated in the pathophysiology of asthma. Glutathione peroxidase 4 (GPX4), the key enzymatic suppressor of ferroptosis, has a role in asthma that remains insufficiently defined. Here, we investigated the regulatory function of GPX4 in asthma airway epith...

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Principais autores: Zehong Chen, Jihao Cai, Shijia Wang, Wei Yu, Feifei Yu, Ruimin Zhou, Chang Cai
格式: Artigo
語言:Inglês
出版: BMC 2026-02-01
叢編:Respiratory Research
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在線閱讀:https://doi.org/10.1186/s12931-026-03584-8
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