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GPX4 alleviates airway inflammation by suppressing 5-LO expression and regulating ferroptosis

Abstract Ferroptosis has been increasingly implicated in the pathophysiology of asthma. Glutathione peroxidase 4 (GPX4), the key enzymatic suppressor of ferroptosis, has a role in asthma that remains insufficiently defined. Here, we investigated the regulatory function of GPX4 in asthma airway epith...

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Bibliografische gegevens
Hoofdauteurs: Zehong Chen, Jihao Cai, Shijia Wang, Wei Yu, Feifei Yu, Ruimin Zhou, Chang Cai
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2026-02-01
Reeks:Respiratory Research
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Online toegang:https://doi.org/10.1186/s12931-026-03584-8
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