Considerations to practice a safe and minimal administration of heparin and protamine during cardiopulmonary bypass

A critical aspect of cardiopulmonary bypass (CPB) is achieving full anticoagulation to prevent thrombosis and consumptive coagulation (CCA). Systemic anticoagulation with heparin during CPB should be completely neutralized by administering protamine to restore normal hemostasis. Activated clotting t...

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Principais autores:	Lee Min-Ho, Shann Kenneth G., Rosenthal Tami
Formato:	Artigo
Idioma:	Inglês
Publicado:	EDP Sciences 2026-06-01
Series:	The Journal of ExtraCorporeal Technology
Assuntos:	target act protamine-to-heparin ratio poct act device optimal protamine dose consumptive coagulation
Acceso en liña:	https://ject.edpsciences.org/articles/ject/full_html/2026/02/ject250093/ject250093.html
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