Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast

Impaired protein degradation and mitochondrial dysfunction are believed to contribute to neurodegenerative disorders, including Alzheimer disease (AD). In patients suffering from non-hereditary AD, UBB+1, the frameshift variant of ubiquitin B, accumulated in neurons affected by neurofi...

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Bibliografiske detaljer

Principais autores:	Ralf J. Braun, Cornelia Sommer, Christine Leibiger, Romina J.G. Gentier, Verónica I. Dumit, Katrin Paduch, Tobias Eisenberg, Lukas Habernig, Gert Trausinger, Christoph Magnes, Thomas Pieber, Frank Sinner, Jörn Dengjel, Fred W. van Leeuwen, Guido Kroemer, Frank Madeo
Format:	Artigo
Sprog:	Inglês
Udgivet:	Shared Science Publishers OG 2015-03-01
Serier:	Microbial Cell
Fag:	Alzheimer’s disease ubiquitin proteasome UBB+1 Cdc48 Vms1 ANKZF1 ZNF744 mitochondria basic amino acids arginine ornithine lysine Saccharomyces cerevisiae apoptosis necrosis programmed cell death
Online adgang:	http://microbialcell.com/researcharticles/modeling-non-hereditary-mechanisms-of-alzheimer-disease-during-apoptosis-in-yeast/
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