Misframed ubiquitin and impaired protein quality control; an early event in Alzheimer’s disease

Aβ plaque formation is a prominent cellular hallmark of Alzheimer’s disease (AD). To date, immunization trials in AD patients have not been effective in terms of curing or ameliorating dementia. In addition, γ-secretase inhibitor strategies await clinical improvements in AD. These approaches were ba...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Romina Jozefa Gentier, Fred W. Van eLeeuwen
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2015-09-01
Цуврал:	Frontiers in Molecular Neuroscience
Нөхцлүүд:	tau Proteins neurodegeneration amyloid precursor protein Proteasome mRNA surveillance frameshift mutation
Онлайн хандалт:	http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00047/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!