Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions
The beta-blocker metoprolol (the sixth most commonly prescribed drug in the USA in 2017) is subject to considerable drug–gene interaction (DGI) effects caused by genetic variations of the <i>CYP2D6</i> gene. CYP2D6 poor metabolizers (5.7% of US population) show approximately five-fold higher metopro...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
MDPI AG
2020-12-01
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| Series: | Pharmaceutics |
| Assuntos: | |
| Acceso en liña: | https://www.mdpi.com/1999-4923/12/12/1200 |
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