Prediction of Drug–Drug–Gene Interaction Scenarios of (<i>E</i>)-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling

Clomiphene, a selective estrogen receptor modulator (SERM), has been used for the treatment of anovulation for more than 50 years. However, since (<i>E</i>)-clomiphene ((<i>E</i>)-Clom) and its metabolites are eliminated primarily via Cytochrome P450 (CYP) 2D6 and CYP3A4, exposure can be affected by...

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Автори:	Christina Kovar, Lukas Kovar, Simeon Rüdesheim, Dominik Selzer, Boian Ganchev, Patrick Kröner, Svitlana Igel, Reinhold Kerb, Elke Schaeffeler, Thomas E. Mürdter, Matthias Schwab, Thorsten Lehr
Формат:	Artigo
Мова:	Inglês
Опубліковано:	MDPI AG 2022-11-01
Серія:	Pharmaceutics
Предмети:	clomiphene pharmacokinetics cytochrome P450 2D6 (CYP2D6) polymorphisms drug–drug interactions (DDIs) drug–drug–gene interactions (DDGIs) drug–gene interactions (DGIs)
Онлайн доступ:	https://www.mdpi.com/1999-4923/14/12/2604
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