Precision screening facilitates clinical classification of BRCA2-PALB2 binding variants with benign and pathogenic functional effects
BACKGROUND Decoding the clinical impact of genetic variants is particularly important for precision medicine in cancer. Genetic screening of mainly patients with breast and ovarian cancer has identified numerous BRCA1/BRCA2 variants of uncertain significance (VUS) that remain unclassified owing to a...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2025-06-01
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| coleção: | The Journal of Clinical Investigation |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1172/JCI181879 |
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