Modulation of pulsatile GnRH dynamics across the ovarian cycle via changes in the network excitability and basal activity of the arcuate kisspeptin network

Pulsatile GnRH release is essential for normal reproductive function. Kisspeptin secreting neurons found in the arcuate nucleus, known as KNDy neurons for co-expressing neurokinin B, and dynorphin, drive pulsatile GnRH release. Furthermore, gonadal steroids regulate GnRH pulsatile dynamics across th...

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Библиографические подробности

Главные авторы:	Margaritis Voliotis, Xiao Feng Li, Ross Alexander De Burgh, Geffen Lass, Deyana Ivanova, Caitlin McIntyre, Kevin O'Byrne, Krasimira Tsaneva-Atanasova
Формат:	Artigo
Язык:	Inglês
Опубликовано:	eLife Sciences Publications Ltd 2021-11-01
Серии:	eLife
Предметы:	GnRH pulse generator KNDy mathematical model optogenetics
Online-ссылка:	https://elifesciences.org/articles/71252
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