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Modulation of pulsatile GnRH dynamics across the ovarian cycle via changes in the network excitability and basal activity of the arcuate kisspeptin network

Pulsatile GnRH release is essential for normal reproductive function. Kisspeptin secreting neurons found in the arcuate nucleus, known as KNDy neurons for co-expressing neurokinin B, and dynorphin, drive pulsatile GnRH release. Furthermore, gonadal steroids regulate GnRH pulsatile dynamics across th...

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Principais autores: Margaritis Voliotis, Xiao Feng Li, Ross Alexander De Burgh, Geffen Lass, Deyana Ivanova, Caitlin McIntyre, Kevin O'Byrne, Krasimira Tsaneva-Atanasova
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2021-11-01
Serier:eLife
Fag:
GnRH pulse generator
KNDy
mathematical model
optogenetics
Online adgang:https://elifesciences.org/articles/71252
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