Combining Auxin-Induced Degradation and RNAi Screening Identifies Novel Genes Involved in Lipid Bilayer Stress Sensing in Caenorhabditis elegans

Alteration of the lipid composition of biological membranes interferes with their function and can cause tissue damage by triggering apoptosis. Upon lipid bilayer stress, the endoplasmic reticulum mounts a stress response similar to the unfolded protein response. However, only a few genes are known...

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Principais autores:	Richard Venz, Anastasiia Korosteleva, Elisabeth Jongsma, Collin Y. Ewald
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2020-11-01
coleção:	G3: Genes, Genomes, Genetics
Assuntos:	lipid bilayer stress lipotoxicity unfolded protein stress auxin-induced degradation creb3 nrf2 mdt-15
Acesso em linha:	http://g3journal.org/lookup/doi/10.1534/g3.120.401635
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