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UPR Induction Prevents Iron Accumulation and Oligodendrocyte Loss in ex vivo Cultured Hippocampal Slices

The accumulation of iron within the brain occurs in many chronic disorders including Alzheimer’s and Parkinson’s disease and multiple sclerosis. Outside the CNS, a link between levels of iron and the unfolded protein response has already been established. To determine if such a relationship operates...

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Principais autores: Sinead Healy, Jill McMahon, Una FitzGerald
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2018-12-01
סדרה:Frontiers in Neuroscience
נושאים:
iron
unfolded protein response
UPR
tunicamycin
ferrocene
גישה מקוונת:https://www.frontiersin.org/article/10.3389/fnins.2018.00969/full
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