TNF-α and IFN-γ prestimulation enhances the therapeutic efficacy of human amniotic epithelial stem cells in chemotherapy-induced ovarian dysfunction

Abstract Background Exposure to a harsh ovarian microenvironment induced by chemotherapeutic agents seriously affects the remodeling of ovarian function and follicular development, leading to premature ovarian failure or insufficiency (POF/POI). For decades, the effectiveness of stem cell therapies...

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Principais autores:	Yating Huang, Qiuwan Zhang, Wenjiao Cao, Qinyu Zhang, Lulu Wang, Dongmei Lai
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2023-11-01
Series:	Inflammation and Regeneration
Assuntos:	Human amniotic epithelial stem cells Premature ovarian failure/insufficiency Inflammatory cytokine Prestimulation Paracrine secretion Oxidative damage
Acceso en liña:	https://doi.org/10.1186/s41232-023-00309-y
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