hAECs restore follicular development in premature ovarian insufficiency via IGFBP2/IGF1R-mediated intercellular communication

Abstract Background Premature ovarian insufficiency (POI) is defined by ovarian dysfunction and consequent decreased fertility. While follicular depletion is an acknowledged factor, dynamic changes in follicular subpopulations and single-cell-level niche remodeling remains largely unexplored. Human...

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Autors principals:	Wenjiao Cao, Lu Shen, Qinyu Zhang, Yating Huang, Junyan Sun, Zixin Cheng, Jing Xu, Qiuwan Zhang, Dongmei Lai
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-05-01
Col·lecció:	Stem Cell Research & Therapy
Matèries:	Premature ovarian insufficiency Human amniotic epithelial cells Single-nucleus RNA sequencing Granulosa cells IGF1R signaling
Accés en línia:	https://doi.org/10.1186/s13287-026-05064-8
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