Distinct Treatment Outcomes of Antiparasitic Therapy in Trypanosoma cruzi-Infected Children Is Associated With Early Changes in Cytokines, Chemokines, and T-Cell Phenotypes

Background: In contrast to adults, Trypanosoma cruzi-infected children have more broadly functional Trypanosoma cruzi-specific T cells, and the total T-cell compartment exhibits fewer signs of immune exhaustion. However, not much is known about the link between immunocompetence and the treatment eff...

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Autori principali:	María C. Albareda, María A. Natale, Ana M. De Rissio, Marisa Fernandez, Alicia Serjan, María G. Alvarez, Gretchen Cooley, Huifeng Shen, Rodolfo Viotti, Jacqueline Bua, Melisa D. Castro Eiro, Myriam Nuñez, Laura E. Fichera, Bruno Lococo, Karenina Scollo, Rick L. Tarleton, Susana A. Laucella
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2018-09-01
Serie:	Frontiers in Immunology
Soggetti:	Trypanosoma cruzi T cells benznidazole nifurtimox pediatric infection
Accesso online:	https://www.frontiersin.org/article/10.3389/fimmu.2018.01958/full
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