Trypanosoma cruzi benznidazole susceptibility in vitro does not predict the therapeutic outcome of human Chagas disease

Therapeutic failure of benznidazole (BZ) is widely documented in Chagas disease and has been primarily associated with variations in the drug susceptibility of Trypanosoma cruzi strains. In humans, therapeutic success has been assessed by the negativation of anti-T. cruzi antibodies, a process that...

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Autors principals:	Margoth Moreno, Daniella A D'ávila, Marcelo N Silva, Lúcia MC Galvão, Andrea M Macedo, Egler Chiari, Eliane D Gontijo, Bianca Zingales
Format:	Artigo
Idioma:	Inglês
Publicat:	Fundação Oswaldo Cruz (FIOCRUZ) 2010-11-01
Col·lecció:	Memorias do Instituto Oswaldo Cruz
Matèries:	Chagas disease benznidazole treatment drug susceptibility microsatellites
Accés en línia:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000700014
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