On the limits of inferring biophysical parameters of RBP-RNA interactions from in vitro RNA Bind’n Seq data [version 3; peer review: 1 approved, 2 approved with reservations, 1 not approved]
We develop a thermodynamic model describing the binding of RNA binding proteins (RBP) to oligomers in vitro. We apply expectation-maximization to infer the specificity of RBPs, represented as position-specific weight matrices (PWMs), by maximizing the likelihood of RNA Bind’n Seq data from the ENCOD...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
F1000 Research Ltd
2026-07-01
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| シリーズ: | F1000Research |
| 主題: | |
| オンライン･アクセス: | https://f1000research.com/articles/12-742/v3 |
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