On the limits of inferring biophysical parameters of RBP-RNA interactions from in vitro RNA Bind’n Seq data [version 3; peer review: 1 approved, 2 approved with reservations, 1 not approved]

We develop a thermodynamic model describing the binding of RNA binding proteins (RBP) to oligomers in vitro. We apply expectation-maximization to infer the specificity of RBPs, represented as position-specific weight matrices (PWMs), by maximizing the likelihood of RNA Bind’n Seq data from the ENCOD...

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Autori principali:	Niels Schlusser, Mihaela Zavolan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	F1000 Research Ltd 2026-07-01
Serie:	F1000Research
Soggetti:	Systems biology bioinformatics computational biology machine learning maximum entropy method Bayesian statistics eng
Accesso online:	https://f1000research.com/articles/12-742/v3
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