Mathematical modelling of stem and progenitor cell dynamics during ruxolitinib treatment of patients with myeloproliferative neoplasms

IntroductionThe Philadelphia chromosome-negative myeloproliferative neoplasms are a group of slowly progressing haematological malignancies primarily characterised by an overproduction of myeloid blood cells. Patients are treated with various drugs, including the JAK1/2 inhibitor ruxolitinib. Mathem...

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Hauptverfasser:	Tobias Idor Boklund, Jordan Snyder, Johanne Gudmand-Hoeyer, Morten Kranker Larsen, Trine Alma Knudsen, Christina Schjellerup Eickhardt-Dalbøge, Vibe Skov, Lasse Kjær, Hans C. Hasselbalch, Morten Andersen, Johnny T. Ottesen, Thomas Stiehl
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2024-05-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	mathematical modelling ordinary differential equations myeloproliferative neoplasms (MPN) parameter estimation JAK2 V617F ruxolitinib
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1384509/full
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