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β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia

Summary: Alzheimer’s disease is the world’s most common neurodegenerative disorder. It is associated with neuroinflammation involving activation of microglia by β-amyloid (Aβ) deposits. Based on previous studies showing apoptosis-associated speck-like protein containing a CARD (ASC) binding and cros...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Lea L. Friker, Hannah Scheiblich, Inga V. Hochheiser, Rebecca Brinkschulte, Dietmar Riedel, Eicke Latz, Matthias Geyer, Michael T. Heneka
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2020-03-01
Rangatū:Cell Reports
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2211124720301868
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