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Computational insights into the inhibitory effects of PFAS 14 on colorectal cancer targeting GSTA1 through competitive binding

This study employed computational biology approaches to investigate the interactions between per- and polyfluoroalkyl substances (PFAS) and key colorectal cancer (CRC) proteins. The results indicate that PFAS may influence CRC progression by modulating multiple proteins, particularly glutathione S-t...

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Principais autores: Jinxiao Li, Yanran Wu, Pian Ye, Dongmei Zuo, Shuangjiao Deng, Ran Pang, Huarong Li
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-03-01
coleção:Ecotoxicology and Environmental Safety
Assuntos:
PFAS
Colorectal cancer
Survival analysis
Computational biology
GSTA1
Competitive binding
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0147651325002611
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