Hepatotoxicity assessment investigations on PFASs targeting L-FABP using binding affinity data and machine learning-based QSAR model

Per- and polyfluoroalkyl substances (PFASs) are persistent organic pollutants that have been detected in various environmental media and human serum, but their safety assessment remains challenging. PFASs may accumulate in liver tissues and cause hepatotoxicity by binding to liver fatty acid binding...

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Principais autores:	Jiayi Zhao, Xiaoyue Shi, Zhiqin Wang, Sijie Xiong, Yongfeng Lin, Xiaoran Wei, Yanwei Li, Xiaowen Tang
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2023-09-01
Serija:	Ecotoxicology and Environmental Safety
Teme:	PFASs L-FABP Binding affinity Machine learning Bayesian Kernel Machine Regression
Online dostop:	http://www.sciencedirect.com/science/article/pii/S014765132300814X
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