Coumarin-chalcone derivatives as dual NLRP1 and NLRP3 inflammasome inhibitors targeting oxidative stress and inflammation in neurotoxin-induced HMC3 and BE(2)-M17 cell models of Parkinson's disease

BackgroundIn Parkinson's disease (PD) brains, microglia are activated to release inflammatory factors to induce the production of reactive oxygen species (ROS) in neuron, and vice versa. Moreover, neuroinflammation and its synergistic interaction with oxidative stress contribute to the pathogenesis...

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Principais autores:	Te-Hsien Lin, Ya-Jen Chiu, Chih-Hsin Lin, Yi-Ru Chen, Wenwei Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Chiung-Mei Chen, Guey-Jen Lee-Chen
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2024-10-01
Serija:	Frontiers in Aging Neuroscience
Teme:	Parkinson's disease therapeutics neuroinflammation oxidative stress MPP+ human HMC3 and BE(2)-M17 cells
Online dostop:	https://www.frontiersin.org/articles/10.3389/fnagi.2024.1437138/full
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