Coumarin-chalcone derivatives as dual NLRP1 and NLRP3 inflammasome inhibitors targeting oxidative stress and inflammation in neurotoxin-induced HMC3 and BE(2)-M17 cell models of Parkinson's disease

BackgroundIn Parkinson's disease (PD) brains, microglia are activated to release inflammatory factors to induce the production of reactive oxygen species (ROS) in neuron, and vice versa. Moreover, neuroinflammation and its synergistic interaction with oxidative stress contribute to the pathogenesis...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Te-Hsien Lin, Ya-Jen Chiu, Chih-Hsin Lin, Yi-Ru Chen, Wenwei Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Chiung-Mei Chen, Guey-Jen Lee-Chen
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Frontiers Media S.A. 2024-10-01
سلاسل:	Frontiers in Aging Neuroscience
الموضوعات:	Parkinson's disease therapeutics neuroinflammation oxidative stress MPP+ human HMC3 and BE(2)-M17 cells
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fnagi.2024.1437138/full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!