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Impact of TGF-β and ERK1/2 inhibition on preimplantation embryo development and quality

Objective(s): Preimplantation embryo culture is a critical phase in assisted reproductive technologies. The use of small molecules to modulate signaling pathways has emerged as a strategy to improve embryo viability. SB431542 inhibits the TGF-β pathway, while PD0325901 inhibits the MEK/ERK pathway....

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Autori principali: Faezah Mohammadi Ghazani, Fatemeh Shirvanizadeh, Seyedeh-Nafiseh Hassani, Azam Dalman, Nahid Nasiri, Maryam Zarei, Saman Maroufizadeh, Poopak Eftekhari Yazdi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mashhad University of Medical Sciences 2026-04-01
Serie:Iranian Journal of Basic Medical Sciences
Soggetti:
mitogen-activated protein kinases/extracellular signal-regulated kinases
pd0325901
pre-implantation embryo
sb431542
transforming growth factor- beta
Accesso online:https://ijbms.mums.ac.ir/article_27437_b6a987e02b57d052d4326593e0178842.pdf
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