Androgen receptor variants occur frequently in castration resistant prostate cancer metastases.

Although androgens are depleted in castration resistant prostate cancer (CRPC), metastases still express nuclear androgen receptor (AR) and androgen regulated genes. We recently reported that C-terminal truncated constitutively active AR splice variants contribute to CRPC development. Since specific...

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Detalhes bibliográficos

Principais autores:	Xiaotun Zhang, Colm Morrissey, Shihua Sun, Melanie Ketchandji, Peter S Nelson, Lawrence D True, Funda Vakar-Lopez, Robert L Vessella, Stephen R Plymate
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2011-01-01
coleção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC3219707?pdf=render
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